We present the first Chandra results of the giant molecular cloud Sagittarius B2 (Sgr B2), located about 100 pc away from the Galactic center. Diffuse X-rays are clearly separated from one-and-a-half dozen resolved point sources. The X-ray spectrum exhibits pronounced iron K-shell transition lines at 6.40 keV (K alpha ) and 7.06 keV (K beta ), deep iron K-edge at 7.11 keV and large photo-electric absorption at low energy. The absorption-corrected X-ray luminosity is 1*1035 erg s-1, two orders of magnitude larger than the integrated luminosity of all the resolved point sources. The diffuse X-rays come mainly from the south-west half of the cloud with a concave-shape pointing to the Galactic center direction. These results strongly support the ASCA model that Sgr B2 is irradiated by an X-ray source at the Galactic center side.